Acne vulgaris is a one of the most common chronic inflammatory disorders of skin affecting adolescents worldwide.
It has been estimated that in USA, more than 40 million people have acne with higher incidence in Africa and Far East areas and of all ethnic groups.
The disease is characterized by the development of follicular rash that starts as comedones followed by formation of inflammatory lesions marked initially by suppuration, followed by granulomatous inflammation due to the proliferation of the bacterium Propionibacterium acne and the activation of the neutrophils, and, over time, by fibrosis and scarring. Approximately half of the total human skin microbiome is composed of P. acnes.
The treatment of acne vulgaris is universally challenging. Current trends of the treatment of acne involve the use of antibiotics which, despite their potency, they show lack bacterial specificity, imbalance human flora, and have a risk of generating drug-resistant bacteria. Other approaches include the use of benzoyl peroxide which acts as an oxidizing agent of bacterial proteins in the sebaceous follicles to decrease the number of anaerobic bacteria. However, it can lead to stinging, dryness, and peeling of skin in addition to the increased risk of developing skin cancer. Alternatively, vitamin A derivatives particularly isotretinoin are powerful and effective choices for the treatment of severe acne only after other treatments have failed. However, isotretinoin has been shown to have serious side effects particularly in cases of pregnancy.
Recently, alternative therapeutic options including herbals, biotech and molecular based products have been used in targeting P. acnes as a direct approach in the treatment and control of acne vulgaris. However, few of them provided promising data.
Recently, the use of Camel based products in improving human health has dramatically emerged. Several studies have shown superior benefits of camel components in the treatment of various bacterial infections and diseases.
Camel milk components, immunoglobulins and other proteins of the innate immune system have shown great potential as biological antimicrobial agents due to their selectivity, availability, safety in addition to their stability in extreme conditions like low pH and high temperatures making them potential options for targeting P. acne associated infection.
Our studies have shown potent antimicrobial activity of whey proteins of camel milk against P. acne both in vitro and in vivo. Today, we use our own scientifically engineered camel milk in a our cosmetic line, SKINUE, that aids in treating acne.back